Pengaruh Suhu dan Lama Penyimpanan Sediaan Krim Antijerawat Mengandung Antibiotik yang Diracik di Apotek Terhadap Aktivitas Antibakteri Staphylococcus aureus
Abstract
AbstrakLatar Belakang : Jerawat merupakan penyakit kulit yang umum terjadi, peradangan dapat dipicu oleh bakteri seperti Propionibacterium acnes, Staphylococcus epidermidis dan Staphylococcus aureus. Sediaan antibiotik topikal seperti neomycin, tetrasiklin, klindamisin, dan kloramfenikol cukup berguna untuk kebanyakan pasien dengan kondisi jerawat ringan hingga parah. Antibiotik topikal dapat berupa salep dan krim yang dapat mengalami perubahan karena dipengaruhi oleh suhu sehingga penyimpanannya harus diperhatikan.
Metode : Jenis penelitian ini adalah penelitian eksperimental karena ada perlakuan terhadap sediaan krim antijerawat racikan yang dipengaruhi suhu dan lama penyimpanan terhadap aktivitas antibakteri dengan cara mengukur diameter zona hambat aktivitas antibakteri. Hasil: Berdasarkan hasil pengukuran diameter zona hambat pada sediaan krim antijerawat racikan yang mengandung antibiotik pada penyimpanan hari ke-28 sediaan mengalami penurunan kecuali pada krim A yang mengandung antibiotik klindamisin mengalami kenaikan.
Kesimpulan : Adanya pengaruh suhu dan lama penyimpanan sediaan krim antijerawat racikan yang mengandung antibiotik terhadap daya hambat bakteri Staphylococcus aureus dengan adanya penurunan daya hambat sediaan diakhir penyimpanan.
Abstract
Background : Acne is a common skin disease, inflammation can be triggered by bacteria like Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. Topical antibiotic preparations such as neomycin, tetracycline, clindamycin, and cloramphenicol are quite useful for most patients with mild to severe acne conditions. Topical antibiotics can be in the form of ointments and creams that can experience changes because they are affected by temperature so that storage must be considered.
Method : This type of research is an experimental research because there is a treatment of preparations for anti-acne creams which are influenced by temperature and storage time for antibacterial activity by measuring the diameter of the inhibitory zone of antibacterial activity.
Results : Based on the measurement of inhibitory zone diameter on antifungal cream preparations containing antibiotics in storage 28 days the dosage decreased except in cream A which contained antibiotic clindamycin increased.
Conclusion : The effect of temperature and storage duration of anti-acne cream preparations containing antibiotics on the inhibitory power of Staphylococcus aureus bacteria with a decrease in dosage inhibition at the end of storage.
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