POTENSI KOLAGEN IKAN TERHADAP PENYEMBUHAN SOKET PASCA PENCABUTAN GIGI

Angelina Natalia Ricardo; Debby Handayati Harahap; Ayeshah A. Rosdah

doi:10.36086/jkgm.v6i2.2577

Angelina Natalia Ricardo Program Studi Magister Ilmu Biomedik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang
Debby Handayati Harahap Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang
Ayeshah A. Rosdah Universitas Sriwijaya

DOI: https://doi.org/10.36086/jkgm.v6i2.2577

Keywords: Kolagen ikan, pencabutan gigi, penyembuhan luka, soket gigi

Abstract

ABSTRAK

Latar Belakang: Pencabutan gigi merupakan prosedur perawatan invasif yang merangsang proses penyembuhan luka yang terdiri dari fase hemostasis, inflamasi, proliferasi, dan remodelling. Dalam berbagai fase penyembuhan, kolagen berperan mempercepat penyembuhan luka dengan cara menghentikan perdarahan, mencegah inflamasi yang berkepanjangan, mendukung angiogenesis, pembentukan jaringan granulasi, dan kontraksi luka. Kolagen umumnya diekstraksi dari kulit atau tulang sapi atau babi, namun kontroversi agama dan risiko penularan penyakit memicu pencarian sumber kolagen alternatif, yaitu ikan. Pemanfaatan kolagen yang diekstraksi dari produk limbah ikan membantu menambah nilai ekonomi dan mengurangi masalah lingkungan. Kolagen ikan bersifat biokompatibel dan memiliki komposisi asam amino yang setara dengan kolagen sapi atau babi. Kesimpulan: Kolagen ikan berpotensi sebagai bahan terapi tambahan untuk mempercepat penyembuhan luka pasca pencabutan gigi karena bersifat biokompatibel, tidak berisiko menularkan penyakit, dan mengandung asam amino yang berperan dalam mendukung proliferasi makrofag, fibroblas, dan epitel, sintesis kolagen, angiogenesis, dan kontraksi luka.

Kata kunci : Kolagen ikan, pencabutan gigi, penyembuhan luka, soket gigi

ABSTRACT

Background : Tooth extraction is an invasive treatment procedure that stimulates the wound healing process, consisting of the hemostasis, inflammation, proliferation, and remodelling phases. In the wound healing phases, collagen plays a role in accelerating wound healing by stopping bleeding, preventing prolonged inflammation, promoting angiogenesis, the formation of granulation tissue, and wound contraction. Generally, collagen is extracted from the skin or bone of bovine or porcine, but religious controversies and the risk of disease transmission have triggered the search for alternative sources of collagen, namely fish. Extracting collagen from fish waste products helps to increase economic value and reduce environmental problems. Fish collagen is biocompatible and have similar amino acid composition to bovine and porcine collagen. Conclusion : Fish collagen has the potential to be an additional therapeutic material to accelerate after tooth extraction healing because that collagen is biocompatible, low risk of disease transmission, and contains amino acids that play role in promoting the proliferation of macrophage, fibroblast, and epithelial cells, collagen sintesis, angiogenesis, and wound contraction.

Keywords : Fish collagen, tooth extraction, tooth socket, wound healing

Author Biographies

Angelina Natalia Ricardo, Program Studi Magister Ilmu Biomedik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang

Program Studi Magister Ilmu Biomedik, Fakultas Kedokteran, Universitas Sriwijaya, Palembang

Debby Handayati Harahap, Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang

Bagian Farmakologi, Fakultas Kedokteran, Universitas Sriwijaya, Palembang

References

1. Rajabimashhadi Z, Gallo N, Salvatore L, Lionetto F. Collagen Derived from Fish Industry Waste: Progresses and Challenges. Polymers 2023;15:544. https://doi.org/10.3390/polym15030544.
2. Silvipriya K, Kumar K, Bhat A, Kumar B, John A, Lakshmanan P. Collagen: Animal Sources and Biomedical Application. J App Pharm Sci 2015:123–7. https://doi.org/10.7324/JAPS.2015.50322.
3. Wang H. A Review of the Effects of Collagen Treatment in Clinical Studies. Polymers 2021;13:3868. https://doi.org/10.3390/polym13223868.
4. Mathew-Steiner SS, Roy S, Sen CK. Collagen in Wound Healing. Bioengineering 2021;8:63. https://doi.org/10.3390/bioengineering8050063.
5. Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol 2020;10:200223. https://doi.org/10.1098/rsob.200223.
6. Udeabor SE, Heselich A, Al-Maawi S, Alqahtani AF, Sader R, Ghanaati S. Current Knowledge on the Healing of the Extraction Socket: A Narrative Review. Bioengineering 2023;10:1145. https://doi.org/10.3390/bioengineering10101145.
7. Ghofrani A, Hassannejad Z. Collagen-Based Therapies for Accelerated Wound Healing. Biochemistry, vol. 0, IntechOpen; 2024. https://doi.org/10.5772/intechopen.1004079.
8. Nurilmala M, Suryamarevita H, Husein Hizbullah H, Jacoeb AM, Ochiai Y. Fish skin as a biomaterial for halal collagen and gelatin. Saudi Journal of Biological Sciences 2022;29:1100–10. https://doi.org/10.1016/j.sjbs.2021.09.056.
9. Gaikwad S, Kim MJ. Fish By-Product Collagen Extraction Using Different Methods and Their Application. Marine Drugs 2024;22:60. https://doi.org/10.3390/md22020060.
10. Afifah A, Suparno O, Haditjaroko L, Tarman K. Utilisation of fish skin waste as a collagen wound dressing on burn injuries: a mini review. IOP Conf Ser: Earth Environ Sci 2019;335:012031. https://doi.org/10.1088/1755-1315/335/1/012031.
11. Meganathan G, Balasubramanian B, Meyyazhagan A, Paul J, Chaudhary A, Pappuswamy M. Review on the fish collagen-based scaffolds in wound healing and tissue engineering. NRFHH 2023;4:1–23. https://doi.org/10.53365/nrfhh/175205.
12. Furtado M, Chen L, Chen Z, Chen A, Cui W. Development of fish collagen in tissue regeneration and drug delivery. Engineered Regeneration 2022;3:217–31. https://doi.org/10.1016/j.engreg.2022.05.002.
13. Lim Y-S, Ok Y-J, Hwang S-Y, Kwak J-Y, Yoon S. Marine Collagen as A Promising Biomaterial for Biomedical Applications. Marine Drugs 2019;17:467. https://doi.org/10.3390/md17080467.
14. Wang T, Yang L, Wang G, Han L, Chen K, Liu P, et al. Biocompatibility, hemostatic properties, and wound healing evaluation of tilapia skin collagen sponges. Journal of Bioactive and Compatible Polymers 2021;36:44–58. https://doi.org/10.1177/0883911520981705.
15. Zata HF, Chiquita P, Shafira K. Collagen from marine source for regenerative therapy: A literature review, Surabaya, Indonesia: 2020, p. 050017. https://doi.org/10.1063/5.0036110.
16. Xu X, Sui B, Liu X, Sun J. Superior low-immunogenicity of tilapia type I collagen based on unique secondary structure with single calcium binding motif over terrestrial mammals by inhibiting activation of DC intracellular Ca2+-mediated STIM1-Orai1/NF-кB pathway. Materials Science and Engineering: C 2021;131:112503. https://doi.org/10.1016/j.msec.2021.112503.
17. Oslan SNH, Li CX, Shapawi R, Mokhtar RAM, Noordin WNMd, Huda N. Extraction and Characterization of Bioactive Fish By-Product Collagen as Promising for Potential Wound Healing Agent in Pharmaceutical Applications: Current Trend and Future Perspective. International Journal of Food Science 2022;2022:1–10. https://doi.org/10.1155/2022/9437878.
18. Jafari H, Lista A, Siekapen MM, Ghaffari-Bohlouli P, Nie L, Alimoradi H, et al. Fish Collagen: Extraction, Characterization, and Applications for Biomaterials Engineering. Polymers 2020;12:2230. https://doi.org/10.3390/polym12102230.
19. Peterson LJ. Peterson’s Principles of Oral and Maxillofacial Surgery. PMPH-USA; 2012.
20. Hupp JR, Tucker MR, Ellis E. Contemporary Oral and Maxillofacial Surgery - E-Book: Contemporary Oral and Maxillofacial Surgery - E-Book. Elsevier Health Sciences; 2013.
21. Landén NX, Li D, Ståhle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci 2016;73:3861–85. https://doi.org/10.1007/s00018-016-2268-0.
22. Barchitta M, Maugeri A, Favara G, Magnano San Lio R, Evola G, Agodi A, et al. Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. IJMS 2019;20:1119. https://doi.org/10.3390/ijms20051119.
23. Fredy Mardiyantoro, Nenny Prasetyaningrum, Miftakhul Cahyati, Zefry Zainal Abidin, Norifumi Nakamura. Potential Effect of Djambal Catfish (Pangasius djambal) Gelatin as Biomaterial Product on Healing Socket after Tooth Extraction in Rats. Indian Journal of Forensic Medicine & Toxicology 2021;15:2379–87. https://doi.org/10.37506/ijfmt.v15i2.14728.
24. Mardiyantoro F, Prasetyaningrum N, Rahmastuti HT. Histopathological characteristics of dental socket healing on collagen density following use of pangas catfish (Pangasius djambal) gelatin. Majalah Kedokteran Gigi Indonesia 2020;5:120. https://doi.org/10.22146/majkedgiind.39830.
25. Kardikadewi VAW, Mardiyantoro F, Prasetyaningrum N, Hidayat LH, Andriani DH, Dianti SP, et al. Stimulation of Dental Socket Healing by Pangasius Djambal Gelatin: Evaluation of Growth Factor Expression. Malaysian Journal of Medicine and Health Sciences 2023;19:9–14.
26. Prahasanti C, Arini NL, Wulan KD, Hendro OV, Wijaksana IKE, Ulfah N, et al. The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen. Dent J 2023;56:115–21. https://doi.org/10.20473/j.djmkg.v56.i2.p115-121.