KORELASI HbA1c DENGAN HEMOGLOBIN DAN LAJU FILTRASI GLOMERULUS PADA PASIEN DIABETES MELLITUS TIPE 2 KOMPLIKASI GAGAL GINJAL KRONIK DI BANJARNEGARA

Authors

DOI:

https://doi.org/10.36086/jpp.v17i2.1379

Keywords:

HbA1c, hemoglobin, LFG, diabetes mellitus, gagal ginjal kronik

Abstract

Latar Belakang: Diabetes melittus atau DM tipe 2 merupakan penyakit yang timbul karena adanya gangguan sekresi insulin pada sel beta pankreas atau resistensi hormon insulin. Tatalaksana diabetes mellitus yang kurang tepat akan menyebabkan kadar glukosa pasien tidak terkontrol sehingga menyebabkan komplikasi seperti neuropati diabetikum serta kondisi anemia yang merupakan masalah yang sering didapatkan penderita diabetes mellitus. Jenis penelitian adalah kuantitatif dengan metode deskriptif korelasional, dengan jumlah sampel 126 rekam medis pasien DM yang dilakukan pemeriksaan HbA1c, Hb, dan serum kreatinin, serta dihitung nilai laju filtrasi glomerulus di Rumah Sakit Emanuel Banjarnegara.

Metode: Pemeriksaan kadar HbA1c menggunakan metode Metode NGSP(National Glycohaemoglobin Standardization Program) yang diambil dari rekam medis pasien, nilai Hb dan serum kreatinin menggunakan metode enzimatik dan laju fitrasi glomerulus dihitung menggunakan rumus Kockcroft-Gault.

Hasil: Hasil riset ini menghasilkan korelasi negatif yang signifikan antara HbA1c dengan hemoglobin ( r = - 0,810; p = 0,000) terdapat korelasi negatif yang signifikan antara HbA1c dan LFG (r = -0,591; p = 0,000), sehingga dapat disimpulkan bahwa nilai kadar HbA1c bertambah tinggi maka nilai hemoglobin dan nilai LFG akan semakin rendah. Kesimpulan: Adanya hubungan bermakna antara HbA1c dengan Hb dan LFG pada penderita diabetes tipe 2 dengan gagal ginjal di Banjarnegara.        Kata kunci: HbA1c, hemoglobin, LFG, diabetes mellitus, gagal ginjal kronik

 

 

ABSTRACT

 

Background: Diabetes mellitus or DM is a disease that arises due to impaired insulin secretion in pancreatic beta cells or insulin hormone resistance. Improper management of diabetes mellitus will cause the patient's glucose levels to be uncontrolled, causing complications such as diabetic neuropathy and anemia, which are the most common problems in people with diabetes mellitus. This research is a quantitative research with a descriptive correlation method, with a sample of 126 medical records of DM patients who were examined for HbA1c, Hb, and serum creatinine, and calculated the value of the glomerular filtration rate at Emanuel Hospital Banjarnegara.Methods: Examination of HbA1c levels using the NGSP (National Glycohaemoglobin Standardization Program) method taken from the patient's medical record, Hb and serum creatinine values ​​using the enzymatic method and the glomerular filtration rate calculated using the Kockcroft-Gault formula.Results: The results of this study showed a significant negative correlation between HbA1c and hemoglobin (r = - 0.810; p = 0.000) there was a significant negative correlation between HbA1c and GFR (r = -0.591; p = 0.000), so it can be concluded that the The higher the HbA1c level, the lower the hemoglobin and GFR values. Conclusion: There is a significant relationship between HbA1c and Hb and GFR in type 2 diabetes patients with kidney failure in Banjarnegara.Keywords: HbA1c, hemoglobin, GFR, diabetes mellitus, chronic renal failure

 

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Published

2022-12-31

Issue

Vol. 17 No. 2 (2022): JPP (Jurnal Kesehatan Poltekkes Palembang)

Section

Articles

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