FORMULASI SEDIAAN GEL EKSTRAK ETANOL DAUN SENDUDUK (Melastoma malabathricum L.) TERHADAP UJI KESTABILAN FISIK DAN UJI AKTIVITAS ANTIBAKTERI PADA STAPHYLOCOCCUS AUREUS
Abstract
Telah dilakukan penelitian tetang Formulasi Sediaan Gel Ekstrak Etanol Daun Senduduk (Melastoma malabathricum L.) Terhadap Uji Kestabilan Fisik dan Uji Aktivitas Antibakteri Pada Staphylococcus Aureus. Penelitian ini bersifat eksperimental dengan membuat 3 jenis formula gel yang mengandung ekstrak etanol daun senduduk (Melastoma malabathricum L.) 4% dengan memvariasikan HPMC sebagai gelling agent pada konsentrasi 3%, 3,5% dan 4%. Uji aktivitas antibakteri dilakukan dengan metode difusi agar terhadap bakteri Staphylococcus aureus. Sediaan disimpan selama 28 hari dan dievaluasi pH, viskositas, homogenitas, intensitas warna dan bau serta iritasi kulit pada hari ke-0, ke-7, ke-14, ke-21 dan ke-28.
Metode: Data uji kestabilan fisik yang diperoleh disajikan dalam bentuk tabel dan grafik lalu diinterprestasikan. Sedangkan untuk uji aktivitas antibakteri cara pengolahan dan analisis datanya yaitu menggunakan analisa statistika One Way ANOVA yang dilakukan dengan cara mengukur diameter zona hambat.
Hasil: menunjukan bahwa semakin tinggi konsentrasi HPMC (gelling agent) maka semakin tinggi viskositas dan semakin rendah daya sebar dan pH, namun tidak berpengaruh terhadap homogenitas, warna, bau dan iritasi kulit. Hasil uji antibakteri menunjukkan bahwa pada formula ekstrak I zona hambat berkisar 11 – 16,5 mm, formula II zona hambat berkisar 10 – 16 mm dan pada formula III zona hambat berkisar 10 – 14,5 mm. Uji statistik oneway anova (p<0,05) untuk membandingkan zona hambatan pada sediaan pada hari ke-0, ke-7, ke-14, ke-21 dan ke-28, didapatkan signifikasi 0,412 (p>0.05).
Kesimpulan: Sediaan gel yang mengandung Ekstrak etanol daun senduduk pada Formula I mempunyai kestabilan fisik yang memenuhi persyaratan untuk dibuat sediaan gel.
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